Such usage, to our knowledge has not been studied. In practice, users of anabolic steroids have programs of repetitive use of these agents. The adverse effect of anabolic steroids on High-Density Lipoprotein Cholesterol (HDL-C) and Low-Density Lipoprotein Cholesterol (LDL-C) has been explored in case control studies comparing those using or not using anabolic steroids or by evaluating serum lipids before and after a course of anabolic steroids. However, these agents are still used by certain athletes who wish to accelerate the increase skeletal muscle mass with exercise. The key management of anabolic steroid-induced dyslipidemia is education on the adverse effects of anabolic steroids on the cardiovascular system.Īnabolic steroids are banned substances in competitive sports because they are an exogenous method for performance enhancement in sports that require increased muscle mass or strength.Reinstitution of anabolic steroids repeatedly produced these adverse effects on lipids.HDL-C and LDL-C were normalized 2.5 to 4 months after discontinuation of their usage. Lipid effects from anabolic steroid use are reversible.

Use of anabolic steroids significantly decreases HDL-C (> 90%) and increases LDL-C (~50%).The repeated usage of the anabolic steroids proves the causative effect of anabolic steroids on lipid metabolism producing serum lipids in a range compatible with an increased risk of cardiovascular events.Īnabolic steroids, Lipid metabolism, Atherosclerosis, Cardiovascular risk High LDL-C is universally accepted to be linked to atherosclerosis and low HDL-C is a risk factor for cardiovascular disease.

This represented a 100% increase in LDL and a 90% reduction in HDL cholesterol. In the subsequent follow-up visits, he resumed anabolic steroid use several times with the lowest levels of HDL-C of 0.2-0.1 mmol/L accompanied by the highest levels of LDL-C at 5.8-6.5 mmol/L. After 10 weeks of discontinuation of anabolic steroid, his HDL-C markedly increased to 1.0 mmol/L and LDL-C was reduced to normal at 3.3 mmol/L. His initial lipids were HDL-C of 0.4 mmol/L and LDL-C of 4.6 mmol/L. The objective was to report on the effect of repeated usage of anabolic steroids on LDL and HDL cholesterol.Ī man engaged in body building repeatedly used anabolic steroids over a 5-year period.

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